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Closed Projects

Since October 2008, we have supported more than 145 studies, connecting over 106,000 volunteers with innovative research around the world. These research projects have studied everything from our microbiota to novel breast cancer genes. We have made a point to partner with researchers who are asking important questions that may help eradicate breast cancer.

While these research studies are always different, there is one common factor: our dedicated Army of Women members. With their help, the following supported studies completed enrollment:

This study is examining the effects of a program that was created to help overweight breast cancer survivors lose weight by increasing their physical activity level and developing healthier eating habits. A total of 800 women will be participating in this study across the United States at four research sites: University of California, San Diego, Washington University School of Medicine in St. Louis, University of Alabama at Birmingham, and University of Colorado, Denver. The Call to Action for this study was sent to Army of Women members on June 1, 2011. When the researchers closed enrollment on May 16, 2012, the Army of Women had provided them with 98 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: May 16, 2012

This study at Stanford University, in Calif., is investigating whether acupuncture can reduce sleep disruption and improve sleep in breast cancer survivors. The researchers wanted to enroll 64 volunteers. The Call to Action for this study was sent to Army of Women members on February 23, 2011. The researchers were able to close enrollment on May 16, 2012, after the Army of Women provided them with 170 women who were interested in enrolling in the study.

Date closed: May 16, 2012

The research team is studying two medicines that may help to reduce hot flashes. One is a low dose estrogen pill; the other is a serotonin-based pill called venlafaxine (brand name Effexor XR). The researchers want to know if women who take these medicines have fewer or less severe hot flashes than women who take a placebo (inactive pill). They also want to determine if one medicine is more effective than the other. A total of 304 women will be participating in this study across the United States at three research sites: Massachusetts General Hospital and Brigham and Women’s Hospital/Harvard Medical School, Boston; Group Health Research Institute, in Seattle; and University of Pennsylvania, Department of Obstetrics/Gynecology, Philadelphia. The Call to Action for this study was sent to Army of Women members on March 28, 2012. When the researchers closed enrollment on May 15, 2012, the Army of Women had provided them with 117 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: May 15, 2012

This study at the University of California, Los Angeles, is evaluating the effectiveness of a specially designed mindfulness meditation-based intervention on psychological, behavioral, and biological functioning in women who were diagnosed with breast cancer before age 50. The researchers wanted to enroll 60 volunteers. The Call to Action for this study was sent to Army of Women members on August 31, 2011. The researchers were able to close enrollment on May 8, 2012, after the Army of Women provided them with 75 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: May 8, 2012

This study at Penn State Milton S. Hershey Medical Center, in Hershey, is investigating whether combining raloxifene with a dietary supplement called omega-3 fatty acid has an effect on breast density or urine and blood chemicals associated with breast cancer development. The researchers wanted to enroll 372 volunteers. The Call to Action for this study was sent to Army of Women members on March 17, 2010. When the researchers closed enrollment on April 2, 2012, the Army of Women had provided them with 342 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: April 2, 2012

This study at The Ohio State University, in Columbus, is studying how yoga affects fatigue, immune function, and mood of women treated for breast cancer. The researchers wanted to enroll 200 volunteers. The Call to Action for this study was sent to Army of Women members on February 24, 2009. When the researchers closed enrollment on March 14, 2012, the Army of Women had provided them with 52 women who were interested in enrolling in the study.

Date closed: March 14, 2012

This study at Rush University Medical Center, in Chicago, is investigating what type of bacteria can be found in the intestines and the way the bacteria metabolize estrogen and other female hormones. The researchers wanted to enroll 30 volunteers. The Call to Action for this study was sent to Army of Women members on October 9, 2009. When the researchers closed enrollment on January 31, 2012, the Army of Women had provided them with 342 women who were interested in enrolling in the study.

Date closed: January 31, 2012

In an effort to find the best way to help medical personnel and women diagnosed with breast cancer, researchers at the University of California, Los Angeles, have developed an online survey to understand women’s thoughts, feelings, and behaviors relevant to taking endocrine therapies. The researchers wanted to enroll at least 500 volunteers. The Call to Action for this study was sent to Army of Women members on January 11, 2012. The researchers were able to close enrollment on January 23, 2012, after the Army of Women provided them with 2,483 women who were interested in enrolling in the study.

Date closed: January 23, 2012

This study at Yale University, in New Haven, Conn., is examining the DNA of women who have had ductal carcinoma in situ (DCIS) and have the BRCA1 or BRCA2 mutation. The researchers wanted to enroll 200 volunteers. The Call to Action for this study was sent to Army of Women members on January 6, 2010. The researchers were able to close enrollment on January 20, 2012, after the Army of Women had provided them with 200 women who were interested in enrolling in the study.

Date closed: January 20, 2012

This study will collect the PGE-M and COX-2 IHC levels in subjects with breast cancer to establish whether urinary PGE-M can be used as a surrogate marker for increased COX-2 expression.

AIMS:
1. The primary objective is to determine the level of PGE-M in the urine of breast cancer patients.
2. The secondary objective is to correlate PGE-M expression in urine expression of COX-2 through IHC in tumor tissue.
3. The third objective is to test the difference in urinary PGE-M level between the patients with tumor and patients without tumor.

To pursue above mentioned hypothesis and aims, we plan to study female patients ≥18 years of age with either metastatic or early stage breast cancer with intact tumor and patients who have been recently diagnosed with breast cancer and are currently tumor-free.

One urine sample and one tumor sample from tumor paraffin blocks (5 slides minimum) will be taken from approximately 340 breast cancer patients according to the following scheme:
80 Her2/neu positive by IHC or FISH positive (any ER/PR) patients
80 ER+ and/or PR+ patients/Her2/neu negative by IHC or FISH negative
80 triple negative patients (Her2/neu negative by IHC or FISH negative, ER-, PR)
100 recently diagnosed patients who have had surgical resection and have no tumor present to serve as negative controls, no specific Her2/neu or ER/PR receptor status is required from this group of patients.

Date closed: January 16, 2012

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